Short and Long-Term Effects of Baccharis articulata on Glucose Homeostasis

Molecules

Virginia D. Kappel¹  Danielle F. Pereira¹  Luisa H. Cazarolli¹  Samantha M. Guesser¹  Carlos H. Blum da Silva¹  Eloir P. Schenkel¹  Flávio H. Reginatto¹ 

[1] ¹Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Cx. Postal 5069, CEP 88040-970, Florianópolis, SC, Brazil

关键词: Baccharis articulata;    diabetes;    insulin;    disaccharidase;    glycation;   

DOI  :  10.3390/molecules17066754

来源: mdpi

【 摘 要 】

In this study, the in vivo effect of the crude extract and n-butanol and aqueous residual fractions of Baccharis articulata (Lam.) Pers. on serum glucose levels, insulin secretion and liver and muscle glycogen content, as well as in vitro action on serum intestinal disaccharidase activity and albumin glycation were investigated. Oral administration of the extract and fractions reduced glycemia in hyperglycemic rats. Additionally, the n-butanol fraction, which has high flavonoids content, stimulated insulin secretion, exhibiting an insulinogenic index similar to that of glipizide. Also, the n-butanol fraction treatment significantly increased glycogen content in both liver and muscle tissue. In vitro incubation with the crude extract and n-butanol and aqueous residual fractions inhibited maltase activity and the formation of advanced glycation end-products (AGEs). Thus, the results demonstrated that B. articulata exhibits a significant antihyperglycemic and insulin-secretagogue role. These effects on the regulation of glucose homeostasis observed for B. articulata indicate potential anti-diabetic properties.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.