Retrospective Study of Switching to Insulin Glargine from Neutral Protamine Hagedorn Insulin in Canine Diabetes Mellitus

glargine;NPH;insulin;Mellitus Diabetes;dog;fructosamine;636

수의과대학 수의학과 ;

University:서울대학교 대학원

关键词: glargine;    NPH;    insulin;    Mellitus Diabetes;    dog;    fructosamine;    636;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/133746/1/000000132896.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

This is the retrospective study investigated the glycemic control effect of insulin glargine in canine Diabetes. 32 dogs were included which were treated at Seoul National University Veterinary Medical Teaching Hospital (SNU VMTH) from 2009 January to 2014 January. 17 dogs were treated with NPH (Neutral Protamine Hagedorn) insulin before. They have needed to switch from NPH-based regimen to a glargine-based regimen, due to poor glycemic control by NPH. In the other hand, 15 dogs were treated with NPH insulin and well glycemic controlled. In each group, patients were analyzed for physical examination, CBC, serum biochemical profile, abdominal imaging, their glucose curve including time to duration, blood glucose nadir, dose of insulin, body weight. Data was analyzed by paired t-test with SPSS statistics program. Compared to the NPH group, duration time was prolonged to 54% after switching insulin type in glargine group. In both group, body weight gradually increased. Compared to NPH group, serum fructosamine level in glargine group had tendency to decrease with the passage of the time. 20.0% patients in NPH group and 17.6% patients in glargine group had shown ketonuria. Hypoglycemia was observed in 13.3% patients in NPH group while 5.9% patients in glargine group.These results suggest that it is better to switch into glargine in dogs which have some problems about short duration time, frequent occurrence of ketone in urine and high level in serum fructosamine concentration with NPH insulin.