Bioactive and Biodegradable Nanocomposites and Hybrid Biomaterials for Bone Regeneration

Journal of Functional Biomaterials

Bedilu A. Allo²  Daniel O. Costa²  S. Jeffrey Dixon¹  Kibret Mequanint² 

[1] Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada;Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Ontario N6A 5B9, Canada;

关键词: bioactive glass;    biodegradable polymers;    bone regeneration;    hydroxyapatite;    organic-inorganic hybrid;    nanocomposite;   

DOI  :  10.3390/jfb3020432

来源: mdpi

【 摘 要 】

Strategies for bone tissue engineering and regeneration rely on bioactive scaffolds to mimic the natural extracellular matrix and act as templates onto which cells attach, multiply, migrate and function. Of particular interest are nanocomposites and organic-inorganic (O/I) hybrid biomaterials based on selective combinations of biodegradable polymers and bioactive inorganic materials. In this paper, we review the current state of bioactive and biodegradable nanocomposite and O/I hybrid biomaterials and their applications in bone regeneration. We focus specifically on nanocomposites based on nano-sized hydroxyapatite (HA) and bioactive glass (BG) fillers in combination with biodegradable polyesters and their hybrid counterparts. Topics include 3D scaffold design, materials that are widely used in bone regeneration, and recent trends in next generation biomaterials. We conclude with a perspective on the future application of nanocomposites and O/I hybrid biomaterials for regeneration of bone.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.