5-(5-Aryl-1,3,4-oxadiazole-2-carbonyl)furan-3-carboxylate and New Cyclic C-Glycoside Analogues from Carbohydrate Precursors with MAO-B, Antimicrobial and Antifungal Activities

Molecules

Mohamed Mohamed El-Sadek¹  Seham Yassen Hassan¹  Nagwa Said Abd El-Dayem¹ 

[1] ¹Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt ²Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt

关键词: carbohydrazone;    isopropylidene;    triazole;    oxadiazole;    monoamine oxidase-B;   

DOI  :  10.3390/molecules17067010

来源: mdpi

【 摘 要 】

Cyclization of acyclic C-glycoside derivatives 1a,b to 2a,b as the major isomers, and 4a,b as the minor isomers were carried out. The isopropylidene derivatives 3a,b were prepared, as well as the hydrazide derivative 6, which was condensed with a variety of aldehydes to give hydrazones 7a–e which were also prepared from the compounds 12a–e. Acetylation of 7a,d gave the corresponding acetyl derivatives 8a,d, respectively. In addition, the dicarbonyl compound 9 was prepared in the hydrate form, which reacted with a number of aroylhydrazines to give the corresponding bisaroyl-hydrazones 10a–d, which were cyclized into 1,3,4-oxadiazoles 11a–d. Furthermore, two of the prepared compounds were examined to show the ability to activate MAO-B. In addition a number of prepared compounds showed antibacterial and antiviral activities.

【 授权许可】

CC BY   
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