Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives

Molecules

Mohamed M. El Sadek¹  Nagwa S. Abd El-Dayem¹  Seham Y. Hassan¹  Mohamed A. Mostafa¹ 

[1] Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt; E-Mails:

关键词: oxoindoline;    isopropylidene;    pyrrole;    indole;    isoindole;    oxadiazole;    pyrazole;    antioxidant;   

DOI  :  10.3390/molecules19045163

来源: mdpi

【 摘 要 】

The carbohydrazide 1 was used as the precursor for the synthesis of a number of new aromatic C-nucleosides containing 1,3,4-oxadiazole 7, [1,3,4]oxadiazolo[2,3-a]isoindole 10b and pyrazole units 18. On the other hand, the thiosemicarbazone 20 was used as the key intermediate for synthesis of 1,3,4-oxadiazole and 1,2,4-triazole-3-thione derivatives 21 and 23. The antioxidant activities of the prepared compounds were evaluated. The carbohydrazide 1 in particular was found to have potent antioxidant and antitumor activity.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.