Synthesis and Bioassay of a New Class of Furanyl-1,3,4-Oxadiazole Derivatives

Molecules

Mohamed M. El Sadek¹  Seham Y. Hassan¹  Huda E. Abdelwahab¹ 

[1] Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt; E-Mails:

关键词: carbohydrazide;    oxadiazole;    triazole;    tyrosinase;   

DOI  :  10.3390/molecules18078550

来源: mdpi

【 摘 要 】

Tyrosinase enzyme is a monophenol monoxygenase enzyme, which plays an important role in human as a rate limiting step enzyme for different specific metabolic pathways, as well as its useful application in industry and agriculture. So this study was carried out to test the effect of newly prepared compounds containing 1,3,4-oxadiazoles with different substituted groups on tyrosinase enzyme activity, hoping to use them in the treatment of some diseases arising from tyrosinase activity disorders such as Parkinson’s disease, schizophrenia, autism, attention deficit, hyperactivity disorder, and cancer.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.