Modelling Carbon Nanotubes-Based Mediatorless Biosensor

Sensors

Romas Baronas²  Juozas Kulys¹  Karolis Petrauskas² 

[1] Institute of Biochemistry, Vilnius University, Mokslininku 12, LT-08662 Vilnius, Lithuania; E-Mails:;Faculty of Mathematics and Informatics, Vilnius University, Naugarduko 24, LT-03225 Vilnius, Lithuania; E-Mail:

关键词: modelling;    simulation;    reaction-diffusion;    biosensor;    mediatorless;    SWCNT;   

DOI  :  10.3390/s120709146

来源: mdpi

【 摘 要 】

This paper presents a mathematical model of carbon nanotubes-based mediatorless biosensor. The developed model is based on nonlinear non-stationary reaction-diffusion equations. The model involves four layers (compartments): a layer of enzyme solution entrapped on a terylene membrane, a layer of the single walled carbon nanotubes deposited on a perforated membrane, and an outer diffusion layer. The biosensor response and sensitivity are investigated by changing the model parameters with a special emphasis on the mediatorless transfer of the electrons in the layer of the enzyme-loaded carbon nanotubes. The numerical simulation at transient and steady state conditions was carried out using the finite difference technique. The mathematical model and the numerical solution were validated by experimental data. The obtained agreement between the simulation results and the experimental data was admissible at different concentrations of the substrate.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.