Anti-Platelet Aggregation and Vasorelaxing Effects of the Constituents of the Rhizomes of Zingiber officinale

Molecules

Yu-Ren Liao²  Yann-Lii Leu⁴  Yu-Yi Chan¹  Ping-Chung Kuo³ 

[1] Department of Biotechnology, Southern Taiwan University, Tainan 710, Taiwan;Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan;Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan;Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan;

关键词: anti-platelet aggregation;    vasorelaxing;    Zingiberaceae;    gingerol;    shogaol;   

DOI  :  10.3390/molecules17088928

来源: mdpi

【 摘 要 】

In the present study, the chemical investigation of the bioactive fractions of the rhizomes of Zingiber officinale has resulted in the identification of twenty-nine compounds including one new compound, O-methyldehydrogingerol (1). Some of the isolates were subjected into the evaluation of their antiplatelet aggregation and vasorelaxing bioactivities. Among the tested compounds, [6]-gingerol (13) and [6]-shogaol (17) exhibited potent anti-platelet aggregation bioactivity. In addition, [10]-gingerol (15) inhibited the Ca²⁺-dependent contractions in high K⁺ medium. According to the results in the present research, the bioactivity of ginger could be related to the anti-platelet aggregation and vasorelaxing mechanism.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.