Antithrombotic Effect of the Ethanol Extract of Angelica gigas Nakai (AGE 232)

Life

Joo-Won Suh¹  Hui Jin¹  Hyunwoo Park¹  Min Sang Kim¹  Hanki Lee²  Pia Loreto Werlinger Bravo²  Hirofumi Matsui³ 

[1] Center for Nutraceutical and Pharmaceutical Materials, Myongji University, Yongin 17058, Korea;Graduate School of Interdisciplinary Program of Biomodulation, Myongji University, Yongin 17058, Korea;Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan;

关键词: thrombus formation;    acetylsalicylic acid;    Angelica gigas Nakai;    improvement of blood circulation;    anti-platelet aggregation;    bleeding in the gut;   

DOI  :  10.3390/life11090939

来源: DOAJ

【 摘 要 】

Cardiovascular diseases, such as stroke, are the most common causes of death in developed countries. Ischemic stroke accounts for 85% of the total cases and is caused by abnormal thrombus formation in the vessels, causing deficient blood and oxygen supply to the brain. Prophylactic treatments include the prevention of thrombus formation, of which the most used is acetylsalicylic acid (ASA); however, it is associated with a high incidence of side effects. Angelica gigas Nakai (AG) is a natural herb used to improve blood circulation via anti-platelet aggregation, one of the key processes involved in thrombus formation. We examined the antithrombotic effects of AGE 232, the ethanol extract of A. gigas Nakai. AGE 232 showed a significant reduction in death or paralysis in mice caused by collagen/epinephrine-induced thromboembolism in a dose-dependent manner and inhibition of collagen-induced human platelet aggregation in a concentration-dependent manner. Additionally, AGE 232-treated mice did not show severe bleeding in the gut compared to ASA-treated mice. AGE 232 resulted in a decrease in the number of neutrophils attached to the human umbilical vein endothelial cells (HUVECs) and lower inhibition of COX-1 in response to bleeding and damage to blood vessels, a major side effect of ASA. Therefore, AGE 232 can prevent thrombus formation and stroke.

【 授权许可】

Unknown