Synthesis of Analogues of Gingerol and Shogaol, the Active Pungent Principles from the Rhizomes of Zingiber officinale and Evaluation of Their Anti-Platelet Aggregation Effects

International Journal of Molecular Sciences

Hung-Cheng Shih⁵  Ching-Yuh Chern²  Ping-Chung Kuo³  You-Cheng Wu⁵  Yu-Yi Chan¹  Yu-Ren Liao⁵  Che-Ming Teng⁴ 

[1] Department of Biotechnology, Southern Taiwan University, Tainan 710, Taiwan; E-Mail:;Department of Applied Chemistry, National Chiayi University, Chiayi 600, Taiwan; E-Mail:;Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan; E-Mail:;College of Medicine, Pharmacological Institute, National Taiwan University, Taipei 100, Taiwan; E-Mail:;Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan; E-Mails:

关键词: Zingiber officinale;    ginger;    gingerol;    shogaol;    anti-platelet aggregation;   

DOI  :  10.3390/ijms15033926

来源: mdpi

【 摘 要 】

The present study was aimed at discovering novel biologically active compounds based on the skeletons of gingerol and shogaol, the pungent principles from the rhizomes of Zingiber officinale. Therefore, eight groups of analogues were synthesized and examined for their inhibitory activities of platelet aggregation induced by arachidonic acid, collagen, platelet activating factor, and thrombin. Among the tested compounds, [6]-paradol (5b) exhibited the most significant anti-platelet aggregation activity. It was the most potent candidate, which could be used in further investigation to explore new drug leads.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland