Lochmolins A–G, New Sesquiterpenoids from the Soft Coral Sinularia lochmodes

Marine Drugs

Yen-Ju Tseng¹  Kuo-Ping Shen³  Hui-Li Lin²  Chiung-Yao Huang¹  Chang-Feng Dai⁴ 

[1] Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan;Department of Food and Nutrition, Meiho University, Pingtung 912, Taiwan;Department of Nursing, Meiho University, Pingtung 912, Taiwan;Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan;

关键词: soft coral;    Sinularia lochmodes;    sesquiterpenes;    aromadendrane;    germacrane;   

DOI  :  10.3390/md10071572

来源: mdpi

【 摘 要 】

Seven new sesquiterpenoids, lochmolins A–G (1–7), were isolated from a Taiwanese soft coral Sinularia lochmodes. The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds 1–4 were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protein in RAW264.7 macrophage cells.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.