Cells | |
The Role of Autophagy in Crohn’s Disease | |
Paul Henderson1  | |
[1] Department of Child Life and Health, 20 Sylvan Place, University of Edinburgh, Edinburgh EH9 1UW, UK | |
关键词: autophagy; Crohn’s disease; inflammatory bowel disease; ATG16L1; NOD2; IRGM; | |
DOI : 10.3390/cells1030492 | |
来源: mdpi | |
【 摘 要 】
(Macro)-autophagy is a homeostatic process by which eukaryotic cells dispose of protein aggregates and damaged organelles. Autophagy is also used to degrade micro-organisms that invade intracellularly in a process termed xenophagy. Genome-wide association scans have recently identified autophagy genes as conferring susceptibility to Crohn’s disease (CD), one of the chronic inflammatory bowel diseases, with evidence suggesting that CD arises from a defective innate immune response to enteric bacteria. Here we review the emerging role of autophagy in CD, with particular focus on xenophagy and enteric
【 授权许可】
CC BY
© 2012 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190042771ZK.pdf | 669KB | download |