The Role of Autophagy in Crohn’s Disease

Cells

Paul Henderson¹ 

[1] Department of Child Life and Health, 20 Sylvan Place, University of Edinburgh, Edinburgh EH9 1UW, UK

关键词: autophagy;    Crohn’s disease;    inflammatory bowel disease;    ATG16L1;    NOD2;    IRGM;   

DOI  :  10.3390/cells1030492

来源: mdpi

【 摘 要 】

(Macro)-autophagy is a homeostatic process by which eukaryotic cells dispose of protein aggregates and damaged organelles. Autophagy is also used to degrade micro-organisms that invade intracellularly in a process termed xenophagy. Genome-wide association scans have recently identified autophagy genes as conferring susceptibility to Crohn’s disease (CD), one of the chronic inflammatory bowel diseases, with evidence suggesting that CD arises from a defective innate immune response to enteric bacteria. Here we review the emerging role of autophagy in CD, with particular focus on xenophagy and enteric E. coli strains with an adherent and invasive phenotype that have been consistently isolated from CD patients with ileal disease.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.