Viruses, Autophagy Genes, and Crohn’s Disease

Viruses

Vanessa M. Hubbard¹ 

[1]Skirball Institute of Biomolecular Medicine, Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA

关键词: Crohn’s disease;    inflammatory bowel disease;    norovirus;    MNV;    ATG16L1;    autophagy;    mucosal immunity;    intestine;    Paneth cells;   

DOI  :  10.3390/v3071281

来源: mdpi

【 摘 要 】

The etiology of the intestinal disease Crohn’s disease involves genetic factors as well as ill-defined environmental agents. Several genetic variants linked to this disease are associated with autophagy, a process that is critical for proper responses to viral infections. While a role for viruses in this disease remains speculative, accumulating evidence indicate that this possibility requires serious consideration. In this review, we will examine the three-way relationship between viruses, autophagy genes, and Crohn’s disease and discuss how host-pathogen interactions can mediate complex inflammatory disorders.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.