Surface Treatment of Polymeric Materials Controlling the Adhesion of Biomolecules

Journal of Functional Biomaterials

Fabienne Poncin-Epaillard²  Tjasa Vrlinic²  Dominique Debarnot²  Miran Mozetic⁴  Arnaud Coudreuse³  Gilbert Legeay³  Benaïssa El Moualij¹ 

[1] Centre de Recherche sur les Protéines Prion, Institut de Pharmacie, B36, No. 1 avenue de l’Hôpital, Liège 4000, Belgium;Département Polymères, Institut des Molécules et Matériaux du Mans, LUNAM Université, UMR Université du Maine—CNRS No. 6283, Colloïdes et Interfaces, Avenue Olivier Messiaen Le Mans Cedex 72085, France;CTTM, 20 rue Thalès de Milet, Le Mans 72000, France;Jozef Stefan Institute, Jamova cesta 39, Ljubljana 1000, Slovenia;

关键词: surface;    polymer;    modification;    bioadhesion;    biomolecules;   

DOI  :  10.3390/jfb3030528

来源: mdpi

【 摘 要 】

This review describes different strategies of surface elaboration for a better control of biomolecule adsorption. After a brief description of the fundamental interactions between surfaces and biomolecules, various routes of surface elaboration are presented dealing with the attachment of functional groups mostly thanks to plasma techniques, with the grafting to and from methods, and with the adsorption of surfactants. The grafting of stimuli-responsive polymers is also pointed out. Then, the discussion is focused on the protein adsorption phenomena showing how their interactions with solid surfaces are complex. The adsorption mechanism is proved to be dependent on the solid surface physicochemical properties as well as on the surface and conformation properties of the proteins. Different behaviors are also reported for complex multiple protein solutions.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.