Chromatin modification contributes to senescence associated proliferation arrest

Q Science (General)

Nelson, David Martin ; Adams, Peter

University:University of Glasgow

Department:Institute of Cancer Sciences

关键词: Senescence, chromatin, histone modification;   

Others  :  http://theses.gla.ac.uk/4220/1/2012Nelsonphd.pdf

来源: University of Glasgow

【 摘 要 】

Senescence is a state of permanent proliferation arrest that normal cells undergo in response to shortened telomeres, oncogenic activation and other sources of cellular stress, thus restricting the replicative capacity of impaired or damaged cells. As such, senescence provides a potent mechanism of tumor suppression, but has also been implicated in organismal aging. Senescence is accompanied by profound chromatin remodeling, which reinforces several important features of the senescence program. Consequently, there is considerable interest in elucidating precisely how chromatin structure influences senescence. In the present work, I set out to investigate the role of the H4K20me3 histone modification in senescence, as the mark has been implicated in aging and is commonly lost in human cancers.