The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR

Molecules

Kang In Choe¹  Joo Hee Kwon¹  Kwan Hee Park¹  Myeong Hwan Oh¹  Manh Heun Kim¹  Han Hyuk Kim¹  Su Hyun Cho¹  Eun Kyung Chung¹  Sung Yi Ha¹ 

[1] College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea

关键词: Rhodiola sachalinensis;    antioxidants;    radical scavengers;    Nitric oxide;    HPLC;   

DOI  :  10.3390/molecules171011484

来源: mdpi

【 摘 要 】

Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4′-di-O-β-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.