Echinohalimane A, a Bioactive Halimane-Type Diterpenoid from a Formosan Gorgonian Echinomuricea sp. (Plexauridae)

Marine Drugs

Hsu-Ming Chung³  Li-Chung Hu²  Wei-Hsuan Yen²  Jui-Hsin Su³  Mei-Chin Lu²  Tsong-Long Hwang¹  Wei-Hsien Wang³ 

[1] Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan;National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan;Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan;

关键词: halimane;    echinohalimane;    Echinomuricea;    cytotoxicity;    elastase;   

DOI  :  10.3390/md10102246

来源: mdpi

【 摘 要 】

A new halimane-type diterpenoid, echinohalimane A (1), was isolated from a gorgonian, identified as Echinomuricea sp. The structure of 1 was determined by spectroscopic methods and this compound was found to exhibit cytotoxicity toward various tumor cells and display an inhibitory effect on the release of elastase by human neutrophils. Echinohalimane A (1) is the first halimane analogue from the marine organisms belonging to phylum Cnidaria.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.