Bioactive Compounds from a Gorgonian Coral Echinomuricea sp. (Plexauridae)

Marine Drugs

Hsu-Ming Chung⁶  Pei-Han Hong³  Jui-Hsin Su³  Tsong-Long Hwang⁵  Mei-Chin Lu³  Lee-Shing Fang²  Yang-Chang Wu⁴  Jan-Jung Li³  Jih-Jung Chen¹  Wei-Hsien Wang⁶ 

[1] Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan;National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan;School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan;Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan;;Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan

关键词: Echinomuricea;    echinolabdane;    yonarasterol;    superoxide anion;    elastase;   

DOI  :  10.3390/md10051169

来源: mdpi

【 摘 要 】

A new labdane-type diterpenoid, echinolabdane A (1), and a new sterol, 6-epi-yonarasterol B (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of metabolites 1 and 2 were elucidated by spectroscopic methods. Echinolabdane A (1) possesses a novel tetracyclic skeleton with an oxepane ring jointed to an α,β-unsaturated-γ-lactone ring by a hemiketal moiety, and this compound is the first labdane-type diterpenoid to be obtained from marine organisms belonging to the phylum Cnidaria. 6-epi-Yonarasterol B (2) is the first steroid derivative to be isolated from gorgonian coral belonging to the genus Echinomuricea, and this compound displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.