A General Synthesis of Bis-indolylpiperazine-2,5-diones

Molecules

Stephen Crooke¹ 

[1] ¹Department of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA ²Department of Chemistry, Georgia Southern University, P.O. Box 8064, Statesboro, GA 30460, USA

关键词: indole;    bromination;    dragmacidin derivatives;   

DOI  :  10.3390/molecules171214841

来源: mdpi

【 摘 要 】

The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5′-methoxy-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7′-methyl-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (2) and 3,6-bis-(6′-chloro-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (3), which are characterized by ¹H-NMR.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.