A General Synthesis of Bis-indolylpiperazine-2,5-diones

Molecules

关键词: indole;    bromination;    dragmacidin derivatives;   

DOI  :  10.3390/molecules171214841

来源: DOAJ

【 摘 要 】

The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5′-methoxy-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7′-methyl-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (2) and 3,6-bis-(6′-chloro-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (3), which are characterized by 1H-NMR.

【 授权许可】

Unknown