An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)

Molecules

Jyotirmoy Maity¹ 

关键词: bromination;    sodium monobromoisocyanurate (SMBI);    pyridine-based nucleosides;    purine-based nucleosides;    bromonucleosides;   

DOI  :  10.3390/molecules181012740

来源: mdpi

【 摘 要 】

An efficient and facile strategy has been developed for bromination of nucleosides using sodium monobromoisocyanurate (SMBI). Our methodology demonstrates bromination at the C-5 position of pyrimidine nucleosides and the C-8 position of purine nucleosides. Unprotected and also several protected nucleosides were brominated in moderate to high yields following this procedure.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.