Synthesis of Novel, Potentially Biologically Active Dibenzosuberone Derivatives

Molecules

Sonja Merkaš¹  Mladen Litvić¹  Ivica Cepanec¹ 

[1] Belupo Pharmaceuticals & Cosmetics Ltd., Radnička 224, 10000 Zagreb, Croatia

关键词: Dibenzosuberone;    tricyclic antidepressants;    bromination;    amitriptiline;    noxiptiline;   

DOI  :  10.3390/10121429

来源: mdpi

【 摘 要 】

Novel representatives of the important group of biologically active dibenzosuberone derivatives were prepared: 3,7-dibromo-5-(dimethylaminoethyl-oxyimino)-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene (1), 3,7-dibromo-5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (2) and 1,7-dibromo-5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo-[a,d]-cycloheptene (3). These compounds are potential tricyclic antidepressants (TCAs), which are still the most frequently prescribed antidepressants in many countries.

【 授权许可】

Unknown   
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