Synthesis and Antibacterial Evaluation of Novel Heterocyclic Compounds Containing a Sulfonamido Moiety

Molecules

Mohammad Emad Azab¹  Mohamed M. Youssef¹ 

[1] ¹Organic Synthetic Lab, Chemistry Department, Faculty of Science, Ain Shams University, Cairo 11566, Egypt ²Department of Chemistry, Faculty of Science, Taif University, Taif 21974, Saudi Arabia ^†Present address: Chemistry Department, Faculty of Science, Cairo University, Cairo 12613, Egypt.

关键词: cyanoacetylhydrazide;    sulfonamide;    pyridazines;    pyrazoles;    oxazole;    pyrimidines;    antibacterial activity;   

DOI  :  10.3390/molecules18010832

来源: mdpi

【 摘 要 】

Aiming for the synthesis of new heterocyclic compounds containing a sulfonamido moiety suitable for use as antibacterial agents, the precursor ethyl {[4-N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylazo}cyanoacetate was reacted with a variety of active methylene compounds producing pyran, pyridine and pyridazine derivatives. Also, the reactivity of the precursor hydrazone towards hydrazine derivatives to give pyrazole and oxazole derivatives was studied. On the other hand, treatment of the same precursor with urea, thiourea and/or guanidine hydrochloride furnished pyrimidine and thiazine derivatives, respectively. The newly synthesized compounds were tested for antibacterial activity, whereby eight compounds were found to have high activities.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.