Synthesis and Antibacterial Evaluation of Some Novel Imidazole and Benzimidazole Sulfonamides

Molecules

Nassir N. Al-Mohammed²  Yatimah Alias²  Zanariah Abdullah²  Raied M. Shakir²  Ekhlass M. Taha¹ 

[1] Department of Chemistry, Collage of Science for Women, Baghdad University, Aljadriya 10071, Baghdad, Iraq;Chemistry Department, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia

关键词: sulfonamide;    4-methylbenzenesulfonamide;    4-nitrobenzenesulfonamide;    4-methoxybenzenesulfonamide;    imidazole;    benzimidazole;    antibacterial activity;   

DOI  :  10.3390/molecules181011978

来源: mdpi

【 摘 要 】

Several new substituted sulfonamide compounds were synthesized and their structures were confirmed by ¹H-NMR, ¹³C-NMR, FT-IR, and mass spectroscopy. The antibacterial activities of the synthesized compounds were screened against standard strains of six Gram positive and four Gram negative bacteria using the microbroth dilution assay. Most of the compounds studied showed promising activities against both types of bacteria.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.