Perfluoroalkanesulfonamide Organocatalysts for Asymmetric Conjugate Additions of Branched Aldehydes to Vinyl Sulfones

Molecules

Kosuke Nakashima¹  Miho Murahashi²  Hiroki Yuasa²  Mariko Ina²  Norihiro Tada²  Akichika Itoh²  Shin-ichi Hirashima¹  Yuji Koseki¹ 

[1] Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan;Gifu Pharmaceutical University 1-25-4, Daigaku-nishi, Gifu 501-1196, Japan

关键词: organocatalyst;    sulfonamide;    vinyl sulfone;    conjugate addition;    quaternary stereocenters;    fluorous;   

DOI  :  10.3390/molecules181214529

来源: mdpi

【 摘 要 】

Asymmetric conjugate additions of branched aldehydes to vinyl sulfones promoted by sulfonamide organocatalyst 6 or 7 have been developed, allowing facile synthesis of the corresponding adducts with all-carbon quaternary stereocenters in excellent yields with up to 95% ee.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.