期刊论文详细信息
Molecules
Antioxidant Properties of cis-Z,Z'-3a.7a',7a.3a'-Dihydroxy-ligustilide on Human Umbilical Vein Endothelial Cells in Vitro
Weidong Li1  Yu Wu1  Xuedong Liu1  Cuiping Yan1  Dan Liu1  Yang Pan1  Guangming Yang1  Fangzhou Yin1  Zebin Weng1  Ding Zhao1  Zhipeng Chen1 
[1] 1College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China
关键词: cis-Z;    -3a.7a'"'>Z'-3a.7a';    7a.3a'-dihydroxyligustilide;    antioxidant;    human umbilical vein endothelial cell;    cell cycle;   
DOI  :  10.3390/molecules18010520
来源: mdpi
PDF
【 摘 要 】

A new chemical component, cis-Z,Z'-3a.7a',7a.3a'-dihydroxyligustilide, was isolated from Angelica sinensis and its structure elucidated from its NMR and MS spectra and confirmed by X-ray single crystal diffraction analysis. We also explored the antioxidative properties of cis-Z,Z'-3a.7a',7a.3a'-dihydroxyligustilide on human umbilical vein endothelial cells (HUVECs) against injuries induced by hydrogen peroxide (H2O2) using an MTT assay and flow cytometry analysis. In addition, the activities of superoxide dismutase (SOD), malondialdehyde (MDA), lactate dehydrogenase (LDH), nitric oxide (NO) and reactive oxygen species (ROS) were determined. We found that cis-Z,Z'-3a.7a',7a.3a'-dihydroxyligustilide increased the viability of HUVECs injured by H2O2 in a dose-dependent manner, reduced the apoptosis of HUVEC, and enhanced HUVEC proliferation. Our results demonstrated the remarkable in vitro antioxidative activities of this compound, indicating that it could be a potential antioxidant with protective effects against H2O2-induced HUVEC injuries.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

【 预 览 】
附件列表
Files Size Format View
RO202003190039363ZK.pdf 1230KB PDF download
  文献评价指标  
  下载次数:4次 浏览次数:3次