Microwave-Assisted Improved Synthesis ofPyrrolo[2,3,4-kl]acridine and Dihydropyrrolo[2,3,4-kl]acridine Derivatives Catalyzed by Silica Sulfuric Acid

Molecules

Chengpao Cao¹  Changliang Xu¹  Wei Lin¹  Xuemei Li¹  Minghua Hu¹  Juxian Wang¹  Zhibin Huang¹  Daqing Shi¹ 

[1] ¹Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

关键词: pyrrolo[2;    3;    4-kl]acridine;    silica sulfuric acid;    microwave irradiation;   

DOI  :  10.3390/molecules18021613

来源: mdpi

【 摘 要 】

An improved synthesis of multifunctionalized pyrrolo[2,3,4-kl]acridine derivatives with different substituted patterns using silica sulfuric acid (SSA) as a heterogeneous catalyst under microwave irradiation conditions was developed. The reaction could be conducted by using readily available and inexpensive substrates within short periods of 12–15 min. under microwave irradiation. Compared with the conventional methods, the remarkable advantages of this method are milder reaction conditions, operational simplicity, higher yields, short reaction times, and an environmentally friendly procedure.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.