Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease

International Journal of Molecular Sciences

Claudia Giachino¹  Luca Orlando² 

[1] Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Turin, Italy;

关键词: embryonic stem cells;    genotoxic stress;    DNA repair;    aging;    tumor;   

DOI  :  10.3390/ijms14022617

来源: mdpi

【 摘 要 】

Recent studies have shown that mouse embryonic stem cells (mESCs) rely on a distinctive genome caretaking network. In this review, we will discuss how mESCs functionally respond to DNA damage and describe several modifications in mESC DNA damage response, which accommodate dynamic cycling and preservation of genetic information. Subsequently, we will discuss how the transition from mESCs to adult stem/progenitor cells can be involved in the decline of tissue integrity and function in the elderly.

【 授权许可】

CC BY   
© 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.