Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-Dipolar Cycloaddition

Molecules

Florea Dumitrascu²  Emilian Georgescu¹  Florentina Georgescu¹  Marcel Mirel Popa² 

[1] Research Center Oltchim, St. Uzinei 1, Ramnicu Vilcea 240050, Romania; E-Mail:;Center of Organic Chemistry “C. D. Nenitzescu”, Romanian Academy, Spl. Independentei 202B, Bucharest 060023, Romania; E-Mail:

关键词: pyrrolo[2;    1-a]isoquinoline;    one-pot three component;    1;    3-dipolar cycloaddition;   

DOI  :  10.3390/molecules18032635

来源: mdpi

【 摘 要 】

Pyrrolo[2,1-a]isoquinoline derivatives were synthesized by one-pot three-component reactions starting from isoquinoline, 2-bromoacetophenones and different non-symmetrical acetylenic dipolarophiles using 1,2-epoxypropane as solvent. The structure of the compounds was assigned by IR and NMR spectroscopy.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.