The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists

Pharmaceuticals

Huayun Deng¹ 

[1] Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, NY 14831, USA; E-Mail

关键词: GPR35;    benserazide;    catechol;    pyrogallol;   

DOI  :  10.3390/ph6040500

来源: mdpi

【 摘 要 】

Nearly 1% of all clinically used drugs are catecholics, a family of catechol-containing compounds. Using label-free dynamic mass redistribution and Tango β-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin and fenoldopam, display agonistic activity against GPR35.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.