International Journal of Molecular Sciences | |
Specific siRNA Targeting Receptor for Advanced Glycation End Products (RAGE) Decreases Proliferation in Human Breast Cancer Cell Lines | |
AL-Madhagi Radia1  AL-Madhagi Yaser2  Xiaoqian Ma1  Juan Zhang1  Cejun Yang1  Qiong Dong1  Pengfei Rong1  Bin Ye1  Sheng Liu1  | |
[1] Cell Transplantation and Gene Therapy Institute, Department of Radiology, the Third Xiang Ya Hospital of Central South University, Changsha 410013, China; E-Mails:;Center of Molecular Medicine, the First Xiang Ya Hospital of Central South University, Changsha 410078, China; E-Mail: | |
关键词: RAGE; siRNA; proliferation; breast cancer; | |
DOI : 10.3390/ijms14047959 | |
来源: mdpi | |
【 摘 要 】
Receptor for Advanced Glycation End Products (RAGE) is an oncogenic trans-membranous receptor overexpressed in various human cancers. However, the role of RAGE in breast cancer development and proliferation is still unclear. In this study, we demonstrated that RAGE expression levels are correlated to the degree of severity of breast cancer. Furthermore, there is a decrease in the proliferation of all sub-types of breast cancer, MCF-7, SK-Br-3 and MDA-MB-231, as a result of the effect of RAGE siRNA. RAGE siRNA arrested cells in the G1 phase and inhibited DNA synthesis (
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland
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