Effects of Nanotoxicity on Female Reproductivity and Fetal Development in Animal Models

International Journal of Molecular Sciences

Jianling Sun²  Qiu Zhang²  Zhiping Wang¹ 

[1] School of Public Health, Shandong University, Jinan 250100, China; E-Mail:;School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China; E-Mails:

关键词: nanotoxicity;    reproductivity;    development;    animal model;    zebrafish;   

DOI  :  10.3390/ijms14059319

来源: mdpi

【 摘 要 】

The extensive application of nanomaterials in industry, medicine and consumer products has raised concerns about their potential toxicity. The female population is particularly vulnerable and deserves special attention because toxicity in this group may impact both female reproductivity and fetal development. Mouse and zebrafish models each have their own unique features and studies using these models to examine the potential toxicity of various nanoparticles are compared and summarized in this review. Several nanoparticles exhibit detrimental effects on female reproductivity as well as fetal development, and these adverse effects are related to nanoparticle composition, surface modification, dose, exposure route and animal species. Limited studies on the mechanisms of nanotoxicity are also documented and reviewed herein.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland