Epidermal Stem Cells in Orthopaedic Regenerative Medicine

International Journal of Molecular Sciences

Jin Li¹  Gehua Zhen²  Shin-Yi Tsai¹ 

[1] Biomedical Engineering, the Johns Hopkins University School of Medicine, 720 Rutland Ave., Traylor #710B, Baltimore, MD 21205, USA; E-Mails:;Orthopaedic Surgery, the Johns Hopkins University School of Medicine, 720 Rutland Ave., Ross #229, Baltimore, MD 21205, USA; E-Mail:

关键词: epidermal stem cells;    wound healing;    peripheral nerve injury;    spinal cord injury;    molecular biology;    orthopedic regenerative medicine;   

DOI  :  10.3390/ijms140611626

来源: mdpi

【 摘 要 】

In the last decade, great advances have been made in epidermal stem cell studies at the cellular and molecular level. These studies reported various subpopulations and differentiations existing in the epidermal stem cell. Although controversies and unknown issues remain, epidermal stem cells possess an immune-privileged property in transplantation together with easy accessibility, which is favorable for future clinical application. In this review, we will summarize the biological characteristics of epidermal stem cells, and their potential in orthopedic regenerative medicine. Epidermal stem cells play a critical role via cell replacement, and demonstrate significant translational potential in the treatment of orthopedic injuries and diseases, including treatment for wound healing, peripheral nerve and spinal cord injury, and even muscle and bone remodeling.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland