Epigenetic Regulation of Epidermal Stem Cell Biomarkers and Their Role in Wound Healing

International Journal of Molecular Sciences

Sabita N. Saldanha¹  Kendra J. Royston²  Neha Udayakumar²  Trygve O. Tollefsbol² 

[1] Department of Biological Sciences, Alabama State University, Montgomery, AL 36104, USADepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA;

关键词: epigenetics;    wound healing;    skin;    microRNA;    epidermal stem cells;    biomarkers;   

DOI  :  10.3390/ijms17010016

来源: mdpi

【 摘 要 】

As an actively renewable tissue, changes in skin architecture are subjected to the regulation of stem cells that maintain the population of cells responsible for the formation of epidermal layers. Stems cells retain their self-renewal property and express biomarkers that are unique to this population. However, differential regulation of the biomarkers can initiate the pathway of terminal cell differentiation. Although, pockets of non-clarity in stem cell maintenance and differentiation in skin still exist, the influence of epigenetics in epidermal stem cell functions and differentiation in skin homeostasis and wound healing is clearly evident. The focus of this review is to discuss the epigenetic regulation of confirmed and probable epidermal stem cell biomarkers in epidermal stratification of normal skin and in diseased states. The role of epigenetics in wound healing, especially in diseased states of diabetes and cancer, will also be conveyed.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.