Pericytes, Mesenchymal Stem Cells and the Wound Healing Process

Cells

Stuart J. Mills¹  Allison J. Cowin¹ 

[1] Regenerative Medicine, Mawson Institute, Mawson Lakes, University of South Australia, South Australia 5095, Australia; E-Mail:

关键词: wound healing;    pericytes;    skin;    MSC;   

DOI  :  10.3390/cells2030621

来源: mdpi

【 摘 要 】

Pericytes are cells that reside on the wall of the blood vessels and their primary function is to maintain the vessel integrity. Recently, it has been realized that pericytes have a much greater role than just the maintenance of vessel integrity essential for the development and formation of a vascular network. Pericytes also have stem cell-like properties and are seemingly able to differentiate into adipocytes, chondrocytes, osteoblasts and granulocytes, leading them to be identified as mesenchymal stem cells (MSCs). More recently it has been suggested that pericytes play a key role in wound healing, whereas the beneficial effects of MSCs in accelerating the wound healing response has been recognized for some time. In this review, we collate the most recent data on pericytes, particularly their role in vessel formation and how they can affect the wound healing process.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.