Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization

Molecules

Yuh-Cherng Guo¹  Che-Mai Chang⁴  Wen-Li Hsu⁶  Siou-Jin Chiu³  Yao-Ting Tsai⁴  Yii-Her Chou³  Ming-Feng Hou⁵  Jaw-Yan Wang⁵  Mei-Hsien Lee²  Ke-Li Tsai⁶ 

[1] Department of Pharmacy, Taipei Medical University-Wanfang Hospital, Taipei 11031, Taiwan;Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan;Department of Urology, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan;Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan;Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan;Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan

关键词: indomethacin;    EGF;    COX-2;    cell migration;   

DOI  :  10.3390/molecules18066584

来源: mdpi

【 摘 要 】

Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca²⁺ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.