Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization

Molecules

卷:18

关键词: indomethacin;    EGF;    COX-2;    cell migration;   

DOI  :  10.3390/molecules18066584

来源: DOAJ

【 摘 要 】

Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.

【 授权许可】

Unknown