Bromodomain Proteins in HIV Infection

Viruses

Daniela Boehm¹  Ryan J. Conrad¹ 

[1] Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA; E-Mails:

关键词: bromodomains;    HIV;    PCAF;    PBAF;    p300;    CBP;    TRIM28;    BRD2;    BRD4;   

DOI  :  10.3390/v5061571

来源: mdpi

【 摘 要 】

Bromodomains are conserved protein modules of ~110 amino acids that bind acetylated lysine residues in histone and non-histone proteins. Bromodomains are present in many chromatin-associated transcriptional regulators and have been linked to diverse aspects of the HIV life cycle, including transcription and integration. Here, we review the role of bromodomain-containing proteins in HIV infection. We begin with a focus on acetylated viral factors, followed by a discussion of structural and biological studies defining the involvement of bromodomain proteins in the HIV life cycle. We end with an overview of promising new studies of bromodomain inhibitory compounds for the treatment of HIV latency.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.