Two New Phenolic Glycosides from Gnaphalium affine D. Don and Their Anti-Complementary Activity

Molecules

Junli Li²  Doudou Huang²  Wansheng Chen¹  Zhongxin Xi²  Cheng Chen²  Guanghui Huang² 

[1] Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China;School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China

关键词: Gnaphalium affine;    phenolic glycosides;    anti-complementary activity;   

DOI  :  10.3390/molecules18077751

来源: mdpi

【 摘 要 】

Two new phenolic glycosides, named gnaphaffine A and B (compounds 1 and 2), were isolated from Gnaphalium affine. together with six known compounds, including caffeic acid (3), everlastoside L (4), isorhamnetin-7-O-β-d-glucopyranoside (5), quercetin-3-O-β-d-glucopyranoside (6), scutellarein-7-O-β-d-glucoside (7) and api-genin-7-O-β-d-glucopyranoside (8). Their structures were elucidated by spectroscopic methods, including ESI-MS and 2D NMR spectroscopy (HMQC and HMBC). All compounds were evaluated for their anti-complementary activity on the classical pathway of the complement system in vitro.

【 授权许可】

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© 2013 by the authors; licensee MDPI, Basel, Switzerland.