New phenolic glycosides from Phyllanthus cochinchinensis

Journal of the Brazilian Chemical Society

Lv, Jun-Jiang¹  University of Chinese Academy of Sciences, Beijing, P. R. China¹  Wang, Dong¹  Chinese Academy of Sciences, Kunming, P. R. China¹  Xu, Min¹  Wang, Yan-Ming¹  Zhang, Ying-Jun¹  Yang, Chong-Ren¹  Zhu, Hong-Tao¹  Zhao, Jian-Qiang¹ 

关键词: Phyllantus cochinchinensis;    Euphorbiaceae;    phenolic glycosides;    cytotoxicity;    antimicrobial activity;   

DOI  :  10.5935/0103-5053.20140127

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Chemical investigation of the whole plants of Phyllanthus cochinchinensis (Euphorbiaceae) led to the isolation of three new phenolic glycosides, phyllanthuosides A-C, together with 12 known compounds. Their structures were established on the basis of extensive spectroscopic analysis and chemical methods. Among them, phyllanthuosides A and B are two of the rare phenolic glycosides, featuring with a C6-C3-C6 skeleton. The absolute configurations of phyllanthuosides A and B were established by calculated electric circular dichroism (ECD) using time dependent density functional theory (TDDFT). The isolates were also tested for their cytotoxicity and antimicrobial activity.

【 授权许可】

Unknown