Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions

Nutrients

Sara Castiglioni¹  Alessandra Cazzaniga¹  Walter Albisetti² 

[1] Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Via GB Grassi 74, Milan I-20157, Italy; E-Mails:;Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Commenda 10, Milan I-20157, Italy; E-Mail:

关键词: osteoporosis;    magnesium;    osteoblast;    osteoclast;   

DOI  :  10.3390/nu5083022

来源: mdpi

【 摘 要 】

A tight control of magnesium homeostasis seems to be crucial for bone health. On the basis of experimental and epidemiological studies, both low and high magnesium have harmful effects on the bones. Magnesium deficiency contributes to osteoporosis directly by acting on crystal formation and on bone cells and indirectly by impacting on the secretion and the activity of parathyroid hormone and by promoting low grade inflammation. Less is known about the mechanisms responsible for the mineralization defects observed when magnesium is elevated. Overall, controlling and maintaining magnesium homeostasis represents a helpful intervention to maintain bone integrity.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.