Krempfielins J–M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

Marine Drugs

Yan-Ning Lee²  Chi-Jen Tai²  Tsong-Long Hwang¹ 

[1] Graduate Institute of Natural Products, Chang Gung University, Taoyuan 33302, Taiwan; E-Mail:;Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan; E-Mails:

关键词: Cladiella krempfi;    eunicellin-based diterpenoid;    elastase;    anti-inflammatory agent;   

DOI  :  10.3390/md11082741

来源: mdpi

【 摘 要 】

New four eunicellin-based diterpenoids, krempfielins J–M (1–4) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. The structure of compound 2 is rare due to the presence of the highly oxygenated pattern. Anti-inflammatory activity of 1–6 to inhibit the superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils was also evaluated, and 2 and 4 were shown to possess the ability to inhibit the elastase release.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.