Krempfielins N–P, New Anti-Inflammatory Eunicellins from a Taiwanese Soft Coral Cladiella krempfi

Marine Drugs

Yan-Ning Lee²  Chi-Jen Tai²  Tsong-Long Hwang¹ 

[1] Graduate Institute of Natural Products, Chang Gung University, Taoyuan 33302, Taiwan; E-Mail:;Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan; E-Mails:

关键词: Cladiella krempfi;    eunicellin-type diterpenoid;    anti-inflammatory agent;    elastase;   

DOI  :  10.3390/md12021148

来源: mdpi

【 摘 要 】

Three new eunicellin-type diterpenoids, krempfielins N–P (1–3), were isolated from a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compound 3 exhibited activity to inhibit superoxide anion generation. Both 1 and3, in particular 1, were shown to display significant anti-inflammatory activity by inhibiting the elastase release in FMLP/CB-induced human neutrophils.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.