Krempfielins Q and R, Two New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

International Journal of Molecular Sciences

Chi-Jen Tai¹  Uvarani Chokkalingam¹  Yang Cheng¹  Shou-Ping Shih²  Mei-Chin Lu²  Jui-Hsin Su²  Tsong-Long Hwang³  Jyh-Horng Sheu¹ 

[1] Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails:;Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan; E-Mails:;Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan; E-Mail:

关键词: Cladiella krempfi;    eunicellin-based diterpenoid;    anti-inflammatory activity;   

DOI  :  10.3390/ijms151221865

来源: mdpi

【 摘 要 】

Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory activity of new metabolites to inhibit the superoxide anion generation and elastase release in N-formyl-methionyl-leucyl phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophil cells and cytotoxicity of both new compounds toward five cancer cell lines were reported.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.