Vitamin B12 Metabolism during Pregnancy and in Embryonic Mouse Models

Nutrients

Maira A. Moreno-Garcia¹  David S. Rosenblatt¹ 

[1] Department of Human Genetics, McGill University, 1205 Avenue Docteur Penfield, N5/13,Montreal, Quebec, Canada H3A 1B1; E-Mails:

关键词: cobalamin;    mouse models;    development;    metabolism;    vitamin B₁₂;   

DOI  :  10.3390/nu5093531

来源: mdpi

【 摘 要 】

Vitamin B₁₂ (cobalamin, Cbl) is required for cellular metabolism. It is an essential coenzyme in mammals for two reactions: the conversion of homocysteine to methionine by the enzyme methionine synthase and the conversion of methylmalonyl-CoA to succinyl-CoA by the enzyme methylmalonyl-CoA mutase. Symptoms of Cbl deficiency are hematological, neurological and cognitive, including megaloblastic anaemia, tingling and numbness of the extremities, gait abnormalities, visual disturbances, memory loss and dementia. During pregnancy Cbl is essential, presumably because of its role in DNA synthesis and methionine synthesis; however, there are conflicting studies regarding an association between early pregnancy loss and Cbl deficiency. We here review the literature about the requirement for Cbl during pregnancy, and summarized what is known of the expression pattern and function of genes required for Cbl metabolism in embryonic mouse models.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.