Peptide-Lipid Interactions: Experiments and Applications

International Journal of Molecular Sciences

Stefania Galdiero²  Annarita Falanga²  Marco Cantisani²  Mariateresa Vitiello¹  Giancarlo Morelli² 

[1] Department of Experimental Medicine—Second University of Naples, Via De Crecchio 7, 80138 Napoli, Italy; E-Mail:;Department of Pharmacy, CIRPEB and DFM—University of Naples “Federico II”, Via Mezzocannone 16, 80134 Napoli, Italy; E-Mails:

关键词: peptide;    membrane;    bacteria;    virus;   

DOI  :  10.3390/ijms140918758

来源: mdpi

【 摘 要 】

The interactions between peptides and lipids are of fundamental importance in the functioning of numerous membrane-mediated cellular processes including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier and viral fusion processes. Moreover, a major goal of modern biotechnology is obtaining new potent pharmaceutical agents whose biological action is dependent on the binding of peptides to lipid-bilayers. Several issues need to be addressed such as secondary structure, orientation, oligomerization and localization inside the membrane. At the same time, the structural effects which the peptides cause on the lipid bilayer are important for the interactions and need to be elucidated. The structural characterization of membrane active peptides in membranes is a harsh experimental challenge. It is in fact accepted that no single experimental technique can give a complete structural picture of the interaction, but rather a combination of different techniques is necessary.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland