Acyclic model peptides with ionophoretic activity

FEBS Letters

Ananthanarayanan, V.S.¹  Shastri, B.P.¹  Attah-Poku, S.K.¹  Rehse, P.H.¹ 

[1] Department of Biochemistry, Memorial University of Newfoundland. St. John's, Newfoundland A1B 3X9, Canada

关键词: Peptide ionophore Ion transport Peptide-ion complex β-turn Model membrane Calcium-binding peptide;   

DOI  :  10.1016/0014-5793(86)80510-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two linear synthetic peptides, N-tBoc-Pro-Gly-Ala-NHCH₃ and N-tBoc-Pro-D-Ala-Ala-NHCH₃, have previously been shown by us to complex with Ca²⁺ and form 2:1 (peptide:calcium) complexes. Here we report their binding to Pr³⁺ and demonstrate, by ¹H NMR, the peptide-mediated transport of Pr³⁺ across dimyristoylphosphatidylcholine unilamellar vesicles via a 2:1 ion-sandwich complex.

【 授权许可】

Unknown