In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters

Molecules

Mohamed I. Attia²  Azza S. Zakaria¹  Maha S. Almutairi² 

[1] Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia;Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

关键词: synthesis;    Mannich reaction;    azoles;    oxime esters;    anti-Candida;   

DOI  :  10.3390/molecules181012208

来源: mdpi

【 摘 要 】

Anti-Candida activities of certain new oximes 4a–d and their respective aromatic esters 5a–l are reported. The tested compounds 4a–d and 5a–l exhibited better anti-Candida profiles than fluconazole. Compound 5j, namely (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as the most active congener, with a MIC value of 0.0054 µmol/mL being more potent than both fluconazole (MIC > 1.6325 µmol/mL) and miconazole (MIC value = 0.0188 µmol/mL) as a new anti-Candida albicans agent.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.