Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents

Molecules

Shang-Shing P. Chou¹  Jui-Chi Juan¹  Shwu-Chen Tsay¹  Kuei Pin Huang¹ 

[1] ¹Department of Chemistry, Fu Jen Catholic University, New Taipei 24205, Taiwan ²Department of Chemistry, National Central University, Jhongli 32001, Taiwan ³Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan

关键词: photo-induced DNA-cleavage;    oxime esters;    2;    6-diazaanthracene-9;    10-dione;    4;    5-diazafluoren-9-one;   

DOI  :  10.3390/molecules17033370

来源: mdpi

【 摘 要 】

Two series of oxime esters containing the 2,6-diazaanthracene-9,10-dione bis-(O-benzoyloxime) and 4,5-diazafluoren-9-one O-9-benzoyloxime moieties have been synthesized and tested as photo-induced DNA cleaving agents. All these compounds were found to cleave DNA upon irradiation with 312 nm UV light. The structure-activity relationship of these molecules for DNA cleavage was established. A plausible reaction mechanism is also proposed.

【 授权许可】

CC BY   
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