One-pot synthesis of β-amino carbonyl compounds catalyzed silica supported phenylphosphinic acid

Green Processing and Synthesis

article

Di Liu¹  Jingwei Zhang¹  Chi Zhang¹  Xiaoyan Kou¹ 

[1] College of Chemical and Environmental Engineering, Shandong University of Science and Technology, Economic and Technical Development Zone

关键词: β-amino carbonyl compounds;    Mannich reaction;    silica supported phenylphosphinic acid;    synthesis;   

DOI  :  10.1515/gps-2014-0077

来源: De Gruyter

【 摘 要 】

A simple and facile synthesis of β-amino carbonyl compounds was developed by the one-pot condensation of cyclohexanone, aromatic aldehydes and anilines at 25°C in the presence of silica supported phenylphosphinic acid. β-Amino carbonyl compounds were obtained in moderate to good yields and reasonable diastereoselectivities. This method has the advantages of short reaction time, mild reaction conditions, reusable catalyst, cost efficiency and environment friendly. In addition, acetophenone and aliphatic ketones as reactants were investigated.

【 授权许可】

CC BY